Vitamin K2 regulates nerve cells through the mitochondrial quality control loop

Vitamin K2 regulates nerve cells through the mitochondrial quality control loop

Photographs of the protective activity of the K2 product show the cytotoxicity induced by 6-OHDA in SH-SY5Y cells. Found: Tang Hengfang

In a new study published in Foods, a research group led by Prof. Zheng Zhiming from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences (CAS) received a new study of vitamin K2: regulation of mitochondrial membrane permeability and reduction of inflammation. oxidative stress, thus correcting mitochondrial dysfunction and preventing nerve damage. 6-hydroxydopamine (6-OHDA).

The antioxidant activity of vitamin K2 is a potent neuroprotective molecule, but its action has not been fully described. The 6-OHDA nerve is responsible for the degeneration of dopamine neurons, which can lead to mitochondrial damage and nerve death. It is often used in the pathogenesis of Parkinson’s disease and other neurodegenerative diseases.

In this study, the scientists found that vitamin K2 can prevent nerve damage caused by 6-OHDA by blocking mitochondria.

Vitamin K2 is responsible for the major alteration of apoptosis by regulating the expression of B-cell lymphoma-2 (one of the oncogenes in apoptosis research) and lowering Bax expression. (an important apoptotic phenomenon in the human body), so to speak. the mitochondrial membrane capable of reactive oxygen levels and lowering oxidative stress, according to Drs. Tang Hengfang, the first author of the study.

In addition, it regulates the normal functioning of mitochondrial fusion, division, autophagy and generation, in order to maintain the normal functioning of the mitochondrial quality control loop and repair damaged mitochondria.

The results suggest that vitamin K2 can play a role in the prevention and treatment of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease by correcting nerve damage.

Scientists believe a peptide can block, restore damage to nerve cells

More information:
Hengfang Tang et al, Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop, Foods (2022). DOI: 10.3390 / nu14071504

Presented by the Chinese Academy of Science

Directions: Vitamin K2 regulates nerve cells through the mitochondrial quality control loop (2022, April 14) retrieved April 14, 2022 from nerve-cells-mitochondrial.html

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