The second COVID Booster will not hurt

The FDA and CDC have cleared the way for Americans over 50 to get a second shot of the booster – but they didn’t expect that. all over to that age group to do so. Like many masking and disease management techniques, the fourth disease (or third, for J & Jers in the back) is now a matter of personal decision -making, although a wave of COVID cases expected to break. It leaves millions of Americans and their doctors to do their self-worth assessment.

Or it’s just a problem evaluation. The four sides of the shot are not entirely clear: The best we can say at this point is that the impact of the defense is low or short (with greater benefits for the elderly). But a low increase is better than none – so why not go get one, if only? What, if any, are the associated problems?

The downside of adding complex words is explained. A New York Times Article published Tuesday, “Should You Get Another Booster ?,” which is said to be often exaggerated “gives reduced results.” (Also: It’s better than nothing!) The article also said that there are a lot of raw materials available. be able to lessen thy body a little in blessing, and that is be able to it would be worse for you to avoid it for a long time than to wait. Céline Gounder, a former member of President Joe Biden’s COVID transformation team, pointed out on Twitter yesterday that some “mental health problems” could be exacerbated, including “fatigue and skepticism ”-but, this is more relevant to health officials than any American looking for shots.

For those who are looking for clarity, here is what we know. The second stimulant will come in negative: They will produce effects such as fever and body aches, at about the same level as the effects of the first stimulant; and it will pay off heavily for the American people, thanks The genera that is rejecting billions in COVID funding this month. Other than that, the problems are only theoretical. “There is no good data in humans for SARS-CoV-2 that is often exaggerated to damage the system,” said John Wherry, an immunologist at the University of Pennsylvania.

Some drawbacks can be eliminated quickly. According to one theory, too many stimulants can lead to a condition called “immune exhaustion,” in which a person’s immune -system T cells start, after trying to fight off an object. involved for many years. “They really shake; They don’t work anymore,” said Akiko Iwasaki, an immunologist at Yale. This can affect people with medical conditions such as HIV, or blood disorders. But medications are associated with low, uncommon, detection of coronavirus protein spikes, and there is no evidence that stimulants take four months to destroy someone’s immune system, he said. Iwasaki – although “if you give it to him every week, that’s a different story.”

Another serious problem is also floating around Manawa: Frequent exposure to a vaccine developed around SARS-CoV-2 infection can improve a person’s immune system (via a process called imprinting) without having to worry about it. See new features. The effect may be similar, but it is not supported by evidence and there is no need to worry at this time, said Marion Pepper, an immunologist at the University of Washington.

Having an incorrect shot, in principle, can put you at an immunological deficit in another way, by interfering with your natural response to a previous COVID shot or disease. One more lesson, scheduled to be published on Phone in April, those who received three shots were seen to see their antibody levels rise by a factor of up to 100. fourth See, than a third – much less increase. That’s an example of a “reduction” problem, it doesn’t matter if you just maintain your antibody level. (A lot plus a little is still more than a lot.) But it was Wherry, who led the Phone tell me, a small amount will have toxic effects on other parts of the immune system, and end up limiting the B cells that respond to disease the next time you encounter it.

Here’s how it works: When you get a booster shot or get sick with COVID after being treated, some of your B cells enter a building in the lymphoid tissue called germinal fluid. center, a type of training ground that serves as the other B’s. systems that can respond to a variety of attackers. If you leave those same test sites on for too long, they will also form long -term plasma cells, which will build up in your bone marrow and produce antibodies on a regular basis. But a new stimulant shot could end that process, Pepper told me, leaving you without the full and long -term benefit of those plasma cells.

All in all, the longer you wait between shots, the longer the shield you will get. In animals, Wherry said, the benefits of waiting begin after six months, but in humans, the best delay is not seen. Pepper doesn’t think this drawback will come for those who received their third shot in the past four months, according to the CDC. “I don’t think the motivator will end anything,” he said. He said people would wait about four months after their latest illness for the same reason. But if you have two stimulants in, say, one month, Pepper thinks you’re done me from safe in the long run before having just one.

Wherry is more interested in seeing a customer, even if it’s small and vague. Even if it is four months after your exercise or the last illness, deciding whether to take a shot is a way of weighing in on some short -term protection from the illness (provided by antibodies) with a long -term protection against serious illness and death (the domain of B and T cells), he told me. Wherry said that the elderly give weight first, because, as we age, our B- and T-cell responses are slower. However, everyone should decide with their doctor, taking into account their own health. “A 67 -year -old marathon runner with no comorbidities, no health problems, would be in a very different condition than a 72 -year -old lymphoma patient on replacement medications.”

How about the problem of getting the booster now, and therefore missing the full effects of a new and better COVID vaccine over the next four months? Now, this doesn’t seem like a serious concern. Newer drugs treated with modified spike proteins of the Omicron type currently do not perform better than the original ones. And any new grain that is about something other than a protein spike won’t be affected by an encounter with our current shots, Wherry said. Yale’s Iwasaki, which makes mucosal medications, said many programs are triggered by illness or disease. If we have some kind of ignorance and we need a new kind of medicine to fight it, it takes more than four months to do it and give it away.

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