The nanoparticles are capable of a fast and complex COVID-19 test

Hiki i nā nanoparticles ke hiki i kahi ho'āʻo COVID-19 wikiwiki a paʻakikī

A 3D printer detects temperature changes when SARS-CoV-2 is attached to molecularly imprinted polymer nanoparticles (shown in cm). Food: Edited ACS Beauty 2022, DOI: 10.1021 / helpers.2c00100

Rapid antigen tests can quickly and easily tell a person that they are good for COVID-19. However, because antibody tests are not very rigorous, they cannot detect infections with low viral loads. Now, researchers report on ACS Beauty developed a rapid experiment using molecularly imprinted polymer nanoparticles, rather than antibodies, to detect SARS-CoV-2. It is much easier to retest and perform under extreme conditions than antibody tests.

The gold standard test for COVID-19 disease involves reverse transcription-polymerase chain reaction (RT-PCR). Although this test is rigorous and detailed, it usually takes 1-2 days to get a result, it is expensive and requires specialized lab equipment and trained personnel. In contrast, antigen tests are fast (15-30 minutes), and people can take them home without training. However, they lack heart, which can sometimes lead to deceivers. In addition, the experiments used antibodies against SARS-CoV-2 to detect that it could not withstand wide ranges of temperature and pH. Marloes Peeters and Jake McClements at the University of Newcastle, Francesco Canfarotta at MIP Diagnostics, and colleagues wanted to create a low-cost, fast, powerful and robust COVID-19 experiment using molecularly imprinted polymers. nanoparticles (nanoMIPs) in place of antibodies.

The researchers created nanoMIPs to counteract a small particle, or peptide, of the SARS-CoV-2 protein spike by making molecular imprints, or molds, into nanoparticles. . The size and shape of these nanoscale holes are necessary to identify and bind the printed peptide and, therefore, the whole protein. They attach nanoparticles that strongly bind the peptide to the printing electrodes. After it was demonstrated that nanoMIPs were able to bind SARS-CoV-2, they developed a 3D printing prototype software to detect disease retention by measuring changes in temperature.

When the team added samples from seven nasopharyngeal swabs to the device, water flowed over the electrode, and the researchers observed a change in temperature for the samples previously tested for COVID. -19 and RT-PCR. The test lasted only 15 minutes, and early results showed that it could detect about 6,000 times lower levels of SARS-CoV-2 than a rapid antigen test. Unlike antibodies, nanoMIPs are resistant to high temperatures – which can provide a long -lasting test life at high temperatures – and acidic pH – can be used effectively for the monitoring of SARS -CoV. -2 in wastewater and saline samples. However, in order to ensure a low -dose antigen test than rapid antigen testing, it needs to be tested in more patients, the researchers said.


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More information:
Molecularly Imprinted Polymer Nanoparticles Enable Fast, Reliable, and High Temperature Detection of SARS-CoV-2, ACS Beauty (2022). DOI: 10.1021 / acsensors.2c00100

Presented by the American Chemical Society

Directions: Nanoparticles capable of the fastest and most stable COVID-19 test (2022, April 13) Retrieved 13 April 2022 from https://phys.org/news/2022-04-nanoparticles -enable-sensitive-durable-rapid.html

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