The healthiest sugar substitute you haven’t heard of

This article was first published on February 4, 2019, and has been expanded with more information.

As you can see, inflammation and oxidative damage are the leading cause of most cancer. What you may not know is the importance of nicotinamide adenine dinucleotide hydrogen phosphate (NADPH) and NADPH oxidase, which eliminates NOX, in these processes.

In a recent paper,1James DiNicolantonio, who co -authored my book, “Superfuel,” explains the importance of collagen and glycine in preventing the breakdown of NADPH. DiNicolantonio also co -authored a book with Jason Fung, called “The Longevity Solution,” which explores in depth how collagen and glycine help improve longevity.

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Without enough NADPH, your body cannot restore glutathione when it becomes oxidized. As you can see, glutathione is important for detoxification, and collagen and glycine directly raise your NADPH levels by preventing the enzyme from breaking down NADPH.

Considering the importance of NADPH for optimal health and disease prevention, this is a really important piece of evidence that can make a big difference in many things, even though collagen and glycine are easier to digest. available and easy. But before we get into the details of the effect of glycine on NOX and NADPH, let’s take a look at some of the causes.

What are NADPH and NOX?

NADPH is the reducing form of NADP +. It is a necessary inhibitor for anabolic effects, including lipid synthesis and nucleic acid. NOX is a complex enzyme that binds to the cellular membrane, located directly in the extracellular space. Preventing NOX is an effective strategy to increase NADPH and the ability of your cells to withstand oxidative stress.

NOX is used in a large number of pathological conditions that significantly increase oxidative stress. In fact, according to DiNicolantonio, NOX overactivity is found to be important in a number of health conditions, including but not limited to:

Vascular diseases and vascular complications of other diseases (diabetes, kidney failure, blindness and heart disease for example)

Resistance to insulin

Neurodegenerative diseases such as Alzheimer’s and Parkinson’s



Acne fibrosis

Erectile dysfunction

As explained by DiNicolantonio in a paper2 demonstrating the ability of bilirubin to inhibit NOX concentrations and lower NOX production, as well as the benefits of spirulina for this reason:

“Increased NADPH oxidase [NOX] It is an important factor in the development of microglial proinflammatory… Oxidative stress in adipocytes, mainly from NADPH oxidase activity, has been shown to play an important role in the development of insulin resistance and the skewing of adipokine. and cytokine production in hypertrophied adipocytes. “

Six ways to prevent NOX and increase NADPH

NADPH is used as a reductive reservoir of electrons for antioxidants that become oxidized and inactive. NADPH is also needed to make your steroid hormones and fats. When you have low levels, you are in trouble.

That said, NADPH is considered a living molecule that can be helpful or harmful because of how much of it is in circulation at the moment, so it needs to be properly regulated by your body. For example, while NOX lowers NADPH, it also plays an important role in helping your immune system fight bacteria, and helping your T cells function properly.

Then, to prevent many diseases it is necessary to find a way to prevent or change NOX. The good news is there are many ways to do this that are not expensive and difficult, such as this:

Niacinamide – Taking nicotinamide can help increase your NADPH levels.3

Lower your glucose levels and prevent fructose – The amount of glucose is converted to fructose and lowers your NAD +,4 So keeping your glucose low and avoiding fructose is part of the model.

Dietary ketosis – Ketone metabolism increases the negative redox power of your family of NAD coenzyme redox molecules, helping to control oxidative damage by increasing NADPH and promoting the transcription of the enzymes of antioxidant pathways during the formation of FOXO3a.5

Glycine and collagen – As detailed in the paper shown, glycine and collagen (also known as glycine) also have some NOX-inhibiting effects, thus increasing your NADPH levels.

The way glycine prevents the production of NOX superoxide is by bringing chloride into the chamber, which reduces the ability of the cell to release chloride ions (because , it requires a high chloride gradient). Chloride ions need to bring in electrons to produce superoxide, so by reducing chloride ions, glycine helps to reduce oxidative stress.

Glycine regulates NADPH and has Anticancer action

According to the report,6 Supplemental glycine can be used for “prevention and control of atherosclerosis, heart failure, angiogenesis associated with cancer or retinal diseases and a variety of diseases. Intoxication, with metabolic syndrome. ” Glycine is one of the most effective additives to spirulina, although both eliminate NOX.

The paper also reported on the anti-angiogenic activity of glycine, in relation to its ability to inhibit the growth of blood vessels that feed the stomach. Animal studies, for example, in mice with cancer fed glycine showed inhibition of angiogenesis and gastrointestinal growth, although unrelated. glycine in a positive increase in cancer risk.

DiNicolantonio and his team believe that one of the causes of this antitumor effect is related to the increase in glycine chloride levels in endothelial cells, which then limits the removal of chloride from the brain. endosome. This prevents the production of NOX, which has a pro-angiogenic action (i.e. stimulates the growth of blood vessels in blood diseases). This paper says:7

“This may explain the well-documented anti-angiogenic effects of increasing plasma glycine to high physiological levels. Immune anticancer monitoring should be considered.

The anti-angiogenic effects of glycine may find application in the prevention or treatment of choroidal neovascularization associated with diabetic retinopathy and age-related macular degeneration. It is interesting to determine if the retinal pigment epithelium reflects glycine receptors. “

Glycine also supports good health

NOX plays an important role in heart disease, and by inhibiting NOX (which raises NADPH), glycine can provide protection from cardiovascular problems. DiNicolantonio and his team explained:

“The responsibility of [NOX] Hardening efforts to promote the pro-inflammatory function of the vascular endothelium have been well documented; That is, endothelial [NOX] It plays an important role in atherogenesis. It is safe to say that most of this is true [NOX] Endosomes can be raised, and can be replaced by cytosolic chloride levels.

If so, then we can expect high plasma glycine, by stimulating glycine-activated chloride streams, to suppress endothelial inflammation by counteracting endosomal inflammation. [NOX] do.In addition, the hyperpolarizing effect of glycine in the endothelium can improve vascular health by increasing calcium influx into endothelial cells, which in turn increases the protective activity of endothelial nitric oxide. synthase.

It seems unlikely that, given the documented effect of glycine on macrophages, supplemental glycine can counteract atherogenesis and plaque instability through anti-inflammatory effects. inflammatory in intimal macrophages and foam cells…Glycine can provide antioxidant protection to the heart… In addition, in rats confined to heart failure or angiotensin II administration, the addition of glycine to reduce cardiac hypertrophy may from.

Glycine Supplementation can improve your health

Considering the importance of reducing inflammation and oxidative stress, and the role NOX and NADPH play in these processes, glycine supplementation holds promise as an adjunct. simple and easy. I take one -quarter teaspoon (about 1 gram) twice a day.

Because of the sweet taste of glycine, you can use it as a healthy substitute for tea or coffee. As DiNicolantonio reported, “The safety of intakes as high as 31 grams per day has been proven. The paper also presents several studies showing an increase in glycine. in order to prevent and / or control:8

  • Metabolic Syndrome – As reported in DiNicolantonio’s paper, “In people with metabolic syndrome combined with 15 grams of glycine per day (5 grams three times daily), denial Plasma levels of oxidative stress were up 25 percent relative to placebo “
  • Complications from diabetes
  • Diarrhea and liver failure
  • Cardiac hypertrophy

Glycine supplementation can:9

Helps improve sleep

Take care of the integrity of the cartilage

Reduce the harmful metabolic effects of high fructose foods

To increase glutathione synthesis, more commonly used with N-acetylcysteine ​​(NAC) supplementation

Improves oxidant-scavenging performance by converting pyruvate, a direct purifier of hydrogen peroxide and prevents the formation of old glycation end products.

Antioxidant effects are obtained by increasing the synthesis of heme and bilirubin, although evidence of this is insufficient, and the effect may be low.

Helps cleanse glyphosate – Glyphosate is an analog of the amino acid glycine.10 It sticks in the areas where you need the glycine. Importantly, glycine is used in the detoxification process, so most of us don’t have enough glycine for good detoxification.

To eliminate glyphosate, you need to replenish your body with glycine. Dr. Dietrich Klinghardt, an expert on metal oxidation and its association with chronic diseases, recommends taking 1 teaspoon (4 grams) of glycine twice a day for a few weeks and then lowering the risk. to one -quarter teaspoon (1 gram) two. in the day. This releases glyphosate from your system, allowing it to be eliminated through your urine.

While glycine powder is an easy choice, collagen is another ingredient that is very rich in glycine. If you go this route, I recommend looking for organic grass that is fed on collagen.

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