Evidence continues to suggest that natural sweeteners are harmful to your health. At the heels of research linking natural sweeteners to cancer1 came a study showing that they completed liver detoxification.
The most recent research focused on the non-nutritive sweeteners acesulfame potassium and sucralose, which have been widely used with which sugar has not been converted to calories. Study author Laura Danner, a medical student at the Wisconsin College of Medicine, estimates that 40% of Americans regularly eat sweets.
“In fact, many people don’t realize that these sweeteners are found in the light- or non-sugar versions of yogurts and processed foods and even in non-food products such as herbal teas and some interesting things, “he said in a news release.2
Sweeteners interfere with the cleansing of the liver
Your liver is essential for detoxification, responsible for over 500 functions in your body.3 Foods, medicines and poisons are made through your stomach and, if necessary, are put back into your bloodstream to be consumed by your stomach and intestines. During stage II detoxification, your liver can turn toxins into harmful substances that your body can easily digest.4
In a study presented at the annual meeting of the American Society for Biochemistry and Molecular Biology in April 2022, in Philadelphia, however, it was shown that natural sweeteners – including acesulfame potassium and sucralose – can disrupting the detoxification process of your liver.
Acesulfame potassium and sucralose – Splenda’s nickname – have been shown to inhibit the action of P -glycoprotein, a “protective protein” that is important in protecting living organisms from harmful pathogens. the environment.5
For example, DDT (dichloro-diphenyl-trichloroethane) has been shown to inhibit P-glycoprotein (PGP), which is one reason why the researchers said, “Even in small numbers, it can these pollutants impair the human body’s ability to protect itself.6
Stephanie Olivier-Van Stichelen, Ph.D., lead author of the study, explained that adverse effects can occur at normal levels of consciousness.7
“We have seen the effect of sweeteners on PGP activity in adolescents suspected by eating normal foods and beverages, well below the FDA’s high limits stated. … Detoxification effect in the liver.
For the study, cells and cell-free assays, which provide information on cellular processes such as transport, were studied, showing that natural sweeteners were stimulated in the transport process. can bind PGP, thus preventing the uptake of compounds such as xenobiotics, drugs and theirs. metabolites, short -chain lipids and bile acids.8
The findings could therefore have serious side effects for people taking antidepressants, antibiotics and blood thinners, using PGP as a primary detoxification agent.
In addition, because PGP is responsible for other bodily functions, including the maintenance of blood-brain barrier, researchers have demanded the need for further research to determine the effect. natural flavors to parts other than the liver, and as much as possible. they interfere with drug metabolism. Danner’s place:9
“If future studies are to prove that junk food impairs the body’s detoxification process, it needs to learn the right relationships and determine safe levels of eating for vulnerable groups. It’s important. including the inclusion of specific numbers of non-nutritive fats included in food labels so that people can monitor their diet.
Sweeteners are associated with chronic kidney disease
A study of 102,865 adults from France, published in PLOS Medicine, found that eating healthy foods and eating natural sweeteners was more effective for groups with cancer. The larger cohort study found that more people who ate high levels of natural fats had more cancer compared to non -consumers.10
Among the sweeteners studied were aspartame and acesulfame-K, which were associated with an increased risk of cancer, although aspartame consumption was associated with higher risk of heart disease. breast and obesity -related diseases, such as stomach, liver, colon and rectal diseases.
Specifically, the incidence of breast cancer increased by 13% among consumers of sweets, while the incidence of breast cancer increased by 22% and the incidence increased. of obesity -related cancers up to 15%.11 “These results show that natural flavors, used in a variety of foods and beverages around the world, could suggest a potential change for cancer prevention,” he said. said the researchers.12
It’s about research, considering that aspartame alone is used in 1,400 food products in France and more than 6,000 products around the world. Its high level of flavor – 200 times more than sugar13 – and low -calorie foods are popular among people who are looking to saturate their drinks and their food, without the calories of high sugar. However, his safety was disputed from the beginning. According to the research team:14
“[E]Xperts called for a re -evaluation by public health officials on the role of aspartame in the development of cancer, based on earlier and recent findings in animal models, the in vitro studies, and, to a lesser extent, human data. The data on other compounds raise questions about their role in carcinogenesis in relation to in vivo studies.
Aspartame’s Long History of Carcinogenicity
In 2006, a study led by Drs. Morando Soffritti, a disease researcher from Italy, found that even at low levels, animals develop different types of cancer when fed aspartame.15
Sofritti is the head of the European Ramazzini Foundation of Oncology and Environmental Science, a highly respected, independent and non -profit organization dedicated to cancer prevention for three years. Aspartame -fed rats were found to have “significantly higher brain size” than rats not fed aspartame.16 In addition, US Right to Know states:17
“Harvard researchers in 2012 showed a positive association between taking aspartame and an increased risk of non-Hodgkin’s lymphoma and multiple myeloma in men, and for leukemia in men. and women.18
In a 2014 opinion piece in the American Journal of Industrial Medicine, Maltoni Center researchers wrote in studies submitted by GD Searle that ‘market acceptance’ does not provide adequate scientific support for [aspartame’s] safe and sound. In contrast, the new results… give similar reports of [aspartame’s] the physical body can. ”
A 2020 study further supports preliminary data from the Ramazzini Institute (RI), showing a significant increase in the number of haematopoietic and lymphoid tissue tumors (HLTs) as well as leukemias and lymphomas. female rats exposed to aspartame.
“After a re -evaluation of the HLT cases, the results obtained were consistent with those reported in the previous RI publication and strengthened the APM hypothesis. [aspartame] it has leukemia and lymphomatogenic effects, ”the researchers explained.19
In 2021, a review of Ramazzini Institute data further confirmed that aspartame is carcinogenic to rodents. The researchers found that their research “confirms a very worrying finding that prenatal exposure to aspartame increases cancer risk in rodent children. They confirm the results of basic RI studies.”20
In response, they called on health agencies and the world to re -examine the health risks of aspartame, including prenatal and postpartum exposure.21
Sweeteners affect the stomach microbiota
It is now known that it is important to protect your gut microbiota for optimal health, and that antibiotics can greatly affect the gut microbiota. Not many people know, however, that natural sweeteners such as saccharine, sucralose, aspartame and acesulfame potassium can lead to changes in the gut microbiota similar to those induced by antibiotics.22
In 2021, for the first time, researchers have shown that artificial sweeteners can enhance antibiotic resistance through conjugative gene transfer, and provide insights into the nature of artificial sweeteners. your body at a cellular level, and altering the expression of genes. When natural sweeteners are detected at the single-cell level, the researchers notice harmful changes in the bacteria:23
“The bacteria were shown in the tested compounds to increase reactive oxygen content (ROS), SOS response, and adaptation. In addition, cell membrane permeability was increased to the two parent bacteria under the detoxification of the tested compounds.The expression of genes involved in ROS detoxification, SOS response, and cell membrane permeability was significantly increased under control to taste.
Disruption of the stomach microbiota has also been linked to nonalchoholic fatty liver disease (NAFLD), and sweeteners are also responsible for this condition. NAFLD is the most common inflammatory disease in developed countries,24 Is known to build up too much fat in your liver that is not related to heavy alcohol use.
Although more and more vegetable oils are used in the industry to increase the incidence of NAFLD, natural sweeteners can cause gut dysbiosis to be a bad thing.25
Artificial sweeteners have also been shown to stimulate glucose intolerance by altering the gut microbiota.26 Research led by Eran Elinav of the Weizmann Institute of Science in Rehovot, Israel, first showed that feeding rats sweeteners developed glucose intolerance after 11 weeks. They then showed how the bacteria in the animals altered their glucose response.
Furthermore, a study published in Frontiers in Nutrition in 2022 found changes in the gut microbiota of children of mothers fed low doses of aspartame and the natural herb stevia, say measuring the consumption of “tasty tastants has a lasting and intergenerational impact on gut microbiota, microbial metabolites and immune health.27
They are found in beverages
Most of the research on natural sweeteners has focused on their use in beverages, with beverages used as an option to calculate the amount of use. Ana. However, as the PLOS Medicine group reports, “A more accurate evaluation of the detection of natural flavors from a wide range of ultraprocessed products (e.g., sweetened yogurts, etc.) would be possible. low-fat bowls, ready meals, delicacies on the table). necessary. ”28
In addition, little is known about the cumulative effects of the introduction of artificial sweeteners, even though millions of people consume artificial sweeteners every day. The study concluded, “Our data does not support the use of processed sweeteners as a safe alternative to sugar in foods or beverages … “29
If you want to stop exposing these substances, be aware that they are hidden in many products rather than beverages, such as dairy products, ketchup, salad dressings, etc. cooked and medicinal plants.
It’s a simple trick to satisfy your taste buds if someone – without having the sweetener – eats something bitter. Bitter tastes, such as those from fermented vegetables or water added with lemon or lime juice, help reduce the craving for sweets.