Scientists can change the complexity

Scientists can change the complexity

The high -value bioprinted bioconstructs show the transformation of the complex 4D model. Found: Eben Alsberg and Aixiang Ding

Instead of traditional 3D printing using digital design to make something out of materials such as plastic or resin, 3D bioprinting makes living pieces and tissues out of it. of living cells, or bioinks. The fourth method – changing the format over time – can be achieved by adding features that allow publishers to change multiple times in a pre -arranged or demanding manner. In response to external signals.

Bioprinting 4D constructs provide opportunities for scientists to better model changes during the development, healing and normal functioning of natural tissues and construct complex structures.

A new lesson in the science journal High describes the development of a new solid-state bioink, bonded with bonded microgels, flake-like shape and living cells, for printing 4D processes. This new system can create valuable bioconstructs of cells that can change shape under physiological conditions.

Called “Jammed Micro-Flake Hydrogel for Four-Dimensional Living Cell Bioprinting,” it was written by engineers at the University of Illinois Chicago who developed the bioink and performed experiments on prototype hydrogels.

Their experiments found complex bioconstructs with well-defined configurations and high cell viability, including the formation of 4D cartilage-like tissue. Further studies show significant 3D-to-3D model changes in bioconstructs performed in a single print.

“This bioink system provides an opportunity to inject bioconstructs that can undergo more complex structural changes over time than previously possible. It will lead to relevant investigations of tissue morphogenesis and gain. further advances in chemical engineering, ”says the author of Eben Alsberg, Richard and Loan Hill Chair, whose options are in the departments of biomedical engineering, mechanical and industrial engineering, pharmacology and regenerative medicine, and medicines.

Alsberg said bioink would advance advanced technologies in many ways.

“Bioinks are so-called shear-thinning and fast-curing materials that enable clean printing based on extrusion with high resolution and high reliability without supportive baths. — For example. – bend, twist or involve a number of many deformations. With this system, tissues such as cartilage can be bioengineered with complex structures that grow over time, “says Alsberg. “One of the most important things that has been accomplished is to create a system that allows the production of bioconstructs that can perform complex 3D-to-3D changes.”

“This is the first system to meet the demanding requirements of 4D bioprinting constructs: It injects living cells into bioinks, can penetrate large complex structures, stimulates conversion under physiological conditions , supports long cell life and facilitates desired cell functions such as cell regeneration, ”said Aixiang Ding, the postdoctoral research team at UIC and the paper’s lead author. “We’re trying to translate this system into the medical applications of tissue engineering, because there’s a lack of tissue and donor parts.”

Oju Jeon of UIC, David Cleveland, Kaelyn Gasvoda, Derrick Wells and Sang Jin Lee are the co -authors of the paper.

The new 4D physical transformations are available for morphodynamic engineering

More information:
Aixiang Ding et al, Jammed Micro – Flake Hydrogel for Four – Dimensional Living Cell Bioprinting, High (2022). DOI: 10.1002 / adma.202109394

Presented by the University of Illinois at Chicago

Directions: Bioprint tissue-like scientists built to be able to control, complex changes (2022, March 31) Retrieved April 1, 2022 from -bioprint-tissue-like-capable-complex .html

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