Researchers estimate postpartum growth in childhood for the first time.

Hoʻolālā ka poʻe noiʻi i ka ulu ʻana o ka māmā ma hope o ka hānau ʻana i ka wā kamaliʻi no ka manawa mua

Map of human cell types that are stored through a single classification process. aie: Cell Genomics / Poaha Elizabeth Duong

How do the lungs develop after the first breath outside the stomach? What are the phone events and changes in early life that trigger abuse and illness? To help answer these questions, scientists have developed a single online atlas of the development of postnatal breast cancer in humans and mice.

The research could help provide more detailed information – at the level of individual cells – about the genetic and epigenetic factors that influence disease health throughout human life, e.g. starting from birth.

The work, published in Cell Genomicsled by a team of researchers at the University of California San Diego and the University of North Carolina at Chapel Hill.

By looking at samples of lung tissue from infants and adolescents and mice, the researchers were able to gain information about how it starts and changes. Movement of certain cell types in the lung.

“These are unique examples where we gathered information that during the growth of the tumor was not well studied,” said lead author Thu Elizabeth Duong, a physician-scientist in medicine. pediatric and UC San Diego School of Medicine and pulmonologist. and Rady Children’s Hospital-San Diego. “What’s interesting is the ability to see, through cell proliferation, how light cells function at this stage of development.”

The goal is to build a place called a “guidebook” of human beings. Such a map will serve as a basis for understanding the telephone difference between healthy lungs and chronic diseases. This work represents a small step in developing a guideline for the pediatric population.

“Your respiratory health is changed by what happens in your first years of life. So when things go wrong, we can go back to those early years to find out the root causes of the disease,” he said. said Duong.

Hoʻolālā ka poʻe noiʻi i ka ulu ʻana o ka māmā ma hope o ka hānau ʻana i ka wā kamaliʻi no ka manawa mua

Immunofluorescence imaging of alveolar epithelial cell states in a human lung. aie: Cell Genomics / Poaha Elizabeth Duong

“In cases of pain or disease, we can expand and look at how cell types differ from their counterparts in health directions and what the molecular pathways are under this changes, ”said Kun Zhang, professor and chair of bioengineering at UC San Diego the lead author of the study. “Knowledge and care can be developed based on differences from the curriculum.”

The lungs are the body’s most important defense. They flush in and store the rest of the essentials such as oxygen, while removing wastes such as carbon oxygen. And they filter the air that we breathe. The researchers believe their knowledge here will form the basis for in -depth research into the nature of the environmental impact such as the perception of air pollution and smoking on health and well -being. with diseases at different stages of life.

To build their map, the researchers analyzed post-mortem human lung tissue collected at different times, ranging from one day to 9 years later. the birth. The researchers also collected meat samples from mice at regular intervals between one day and nearly a month after birth.

The researchers used future single-cell sequencing technologies developed in Zhang’s lab to look at single nuclei in more than 80,000 human and mouse cells combined.

With this recording, researchers can begin to document developmental pathways for different cell types including alveolar epithelial type 1 cell. These cells are important for the conversion of carbon dioxide gases. The researchers gained information about how alveolar type 1 cells communicate with other cells such as myofibroblasts, and how this communication can play a role in the growth of alveolar cells. alveolar cell.

The study also showed a significant number of fibroblast cells in the human lung that were not detected in mice. These fibroblasts are cells in the connective tissue that play a role in the structure of the lung. The researchers also found that cell states in a person’s lungs that exist during early life at birth but disappear by 9 years.

“These data are helping us to integrate the different cell types in the lung,” says Duong. “We think this will be a valuable resource for light researchers moving forward.”

Researchers are discovering new cell types in the human lung with regenerative properties

More information:
Thu Elizabeth Duong et al, A single-cell study of postnatal lung alveologenesis in humans and mice, Cell Genomics (2022). DOI: 10.1016 / j.xgen.2022.100108

Presented by the University of California – San Diego

Directions: Researchers paper on postpartum development in childhood for the first time (2022, April 11) retrieved April 11, 2022 from news/2022-04-lung-birth-late-childhood.html

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