Old skins are remodeled to restore youthful function

Old skins are regenerated to regain youthful function

The young fibroblasts in the first image were two after 10 days, on the right side with care, the last two after 13 days, right with care. Red indicates restored collagen production. Found: Fatima Santos, Babraham Institute

Research from the Babraham Institute has developed a way to “fly time” to human skin in 30 years, turning the aging clock for cells without losing their unique function. The work of the researchers in the Epigenetics Institute’s research program has the potential to restore the function of antiquities, as well as rejuvenating the molecular dimensions of biological age. The research is published today in the journal eLifeand while this topic is still in the early stages of research, it can be converted to new medicine.

What is a new medicine?

As we age, our cells are less able to function and the genome collects the signals of aging. Regenerative biology is the idea of ​​repairing or replacing cells with old ones. One of the most important tools in regenerative biology is our ability to create “embedded” cells. The process is the result of several steps, each clearing out some of the signals to stimulate the cells. In theory, these cells could also be different cell types, but scientists could not recreate them by relying on conditions to further separate all cell types.

Looking for the moment

The new approach, based on the Nobel -winning technology used by scientists to create stem cells, overcomes the problem of erasing cell information by cutting down on the reprogramming part of the path in the process. This allowed the researchers to find the right balance between reprogramming cells, enriching them biologically, while being able to restore their unique cellular function.

In 2007, Shinya Yamanaka was the first scientist to turn normal cells, which have a specific function, into stem cells that have the unique ability to develop each cell type. The entire process of stem cell remodeling takes about 50 days using four key molecules called Yamanaka roots. The new method, called “maturation phase transient reprogramming,” exposes the cells to Yamanaka stems for only 13 days. Now, the age -related changes have been removed and the sites have lost their visibility. They were given time to grow under normal conditions, to observe the return of the skin’s function. Genome testing has shown that specific signs of fibroblasts have been obtained, and this has been confirmed by looking at the production of collagen in reprogrammed cells.

Mobility of fibroblast cells as part of the wound healing process. Found: Fátima Santos, film by Hanneke Okkenhaug

The year is not just a number

To show that the cells are regenerated, the researchers looked for changes in the features of aging. As explained by Dr. Diljeet Gill, a postdoc in Wolf Reik’s lab at the Institute who led the work as a Ph.D. student, “We have made progress in observing aging at a molecular level over the past decade, providing technologies that allow researchers to measure age -related biological changes in human systems. We were able to use this in our experiment to determine the extent of reprogramming in our newly acquired pathway. “

The researchers looked at several measurements of the telephone age. The first is the epigenetic clock, where chemical signals around the genome are displayed throughout the year. The second is the transcriptome, all gene readings made by the phone. In these two measurements, the regenerated cells were similar in size to 30 -year -old cells when compared to the reference data sets.

The potential benefits of this technology rely on cells that are not only slightly younger, but also act like younger cells. Fibroblasts secrete collagen, a molecule found in bones, skin and ligaments, which helps supply muscle and heal wounds. New fibroblasts regenerated collagen proteins compared to control cells that did not undergo the reprogramming process. Fibroblasts are also moving to areas that need to be repaired. The researchers tested the regenerated cells by making a functional cut in a row of cells in a cup. They found that their fibroblasts stored in the neck moved more than the older cells. This is a promising sign that one day this research can be used to make cells that are better at healing wounds.

In the future, this research may open up to other therapies; the researchers found that their treatment had an effect on other genes associated with disease and age -related symptoms. The APBA2 gene, associated with Alzheimer’s disease, and the MAF gene, which is responsible for the development of cataracts, both showed changes in young stages of transcription.

The technology behind the transient redesign is not clear, and that is the piece of the puzzle to look for. The researchers believe that important parts of the genome involved in the formation of electronic information could escape the reprogramming process.

Diljeet concluded, “Our results show a significant milestone before we even know cell reprogramming. We have shown that cells can be regenerated without losing their function and focus. rejuvenation restores certain functions to old cells.The fact that we have seen a reversal Old signals to disease -related genes promise a great deal of promise for the future of this process. . “

Professor Wolf Reik, a leader in the Epigenetics research program that recently moved to lead the Altos Labs Cambridge Institute, said, “This work is very interesting. As a result, we are able to identify genes that rejuvenate without rejuvenation, and accurately. reduce the effects of aging. This approach holds the promise of valuable information that can unlock an amazing medical potential. ”

Human pluripotent stem cells work better

More information:
The multi-organism of human cells is regenerated by transient maturation reprogramming, eLife2022. DOI: 10.7554 / eLife.71624

Journal information:

Presented by Babraham Institute

Directions: Old skins remodeled to get more youthful function (2022, April 7) Retrieved April 7, 2022 from https://phys.org/news/2022-04-skin-cells-reprogrammed- regain-youthful.html

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