Cell proliferation of GI bacteria can open up protection against future disease


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Published by Nature Communicationsresearch from the University of Minnesota and the Mayo Clinic sought to understand how microbial communities help people avoid pathogens.

The researchers found that infections were caused by the bacterium Enterococcus faecalis (E. faecalis), a common pathogen in the disease.
gastrointestinal (GI) tract of man, signaling to each other during gene transfer to the stomach of animal species. When E. faecalis becomes unbalanced in the body, it can cause infections in the GI tract.

“We found that the introduction of pheromones into microcolonies in the GI tract reveals that microcolonies associated with the skin of the stomach are an important niche for cell-cell signaling and plasmid transmission,” he said. and Gary Dunny, professor of microbiology and immunology at the U of M School of Medicine.

The lesson is that:

  • the pCF10 plasmid increases the competitiveness of non -antibiotic -resistant bacteria;
  • an intracellular signaling system that regulates plasmid transfer activities in the GI tract; a,
  • The small bacterial biofilms on the skin of the stomach act as an important niche for plasmid signaling and transmission.

This study demonstrated a new effect of a plasmid on the ability of its receptor to colonize and maintain the natural environment, as well as the importance of communication between bacterial cells.

“If you have a bacterial infection, antibiotics go into the treatment. Blocking the bacterial infection is an effective way to prevent or treat hospital infections without increasing the risk of infection.” antibiotic resistance, ‚ÄĚDunny said.

The researchers hope to further learn how to use genetic pathways to further explore the mechanisms of in vivo signaling and plasmid transmission.

The plasmid can be used genetically to fight antimicrobial resistance

More information:
Helmut Hirt et al, Dynamics of plasmid-mediated niche invasion, immunity to invasion, and pheromone-inducible conjugation in the murine gastrointestinal tract, Nature Communications (2022). DOI: 10.1038 / s41467-022-29028-7

Presented by the University of Minnesota School of Medicine

Directions: Cell-cell signaling of GI bacteria can unlock immunity to future disease (2022, April 8) Retrieved 8 April 2022 from https://phys.org/news/2022- 04-cell-cell-gi-bacteria-future-infection. html

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