Biochemical technology to search for small molecules identified by researchers

ʻO ka ʻenehana biochemical no ka ʻimi ʻana i nā moleke liʻiliʻi i ʻike ʻia e nā mea noiʻi

Abstract images. aie: ACS Central Science (2022). DOI: 10.1021 / accentsci.1c01058

Lipid fat, a component of the plasma membrane that surrounds all the cells in the human body, is important in regulating the structure of the membrane, among other functions. But it’s hard to study because traditional biochemicals will destroy them.

Chuck Sanders, associate dean for research, professor of biochemistry and medicine and Aileen M. Lange & Annie Mary Lyle Chair for Cardiovascular Research, and his lab partnered with co -author Anne Kenworthy on University of Virginia School of Medicine to develop new technologies for information. small molecules regulate lipid receptors. Their article is published in ACS Central Science in February 2022.

“Raft-modulatory molecules are an important part of critical processes,” Sanders said. “Lipid compounds like clique in a party – always mix. This work shows how to find small molecules to ‘break’ these molecular cliques or increase their formation. ”

Lipid compounds are formed with lipids and proteins as they move through the plasma membrane, much like small plants in the ocean. They help with phone picking, signal handling and security systems. For example, the enzymes responsible for the production of the amyloid-beta polypeptide closely related to Alzheimer’s disease are thought to reside in lipid receptors.

So learn more about the molecules that regulate lipid raft activity to become a medical disease. In addition to Alzheimer’s disease, lipid replacement therapy has been associated with cancer -resistant patients who are resistant to chemotherapy. These molecules are important researchers that allow researchers to study the roles of rafts in health and disease processes.

“In the short term, the dynamic pathways described in this work will lead to the identification of low molecular weight components that can be used to increase or inhibit the formation of lipid raft in research, ”Sanders said. “In the long run, we hope to have some of the most recognizable molecules in research, biotechnology and medicine.”

The screening technology for a patent is shared by Vanderbilt and the University of Virginia. The Sanders lab will develop and refine the screening process described in this paper.

“We’re looking to expand this approach to identify small molecules that effectively help move membrane proteins in and out of lipid receptors,” Sanders said.

The body is dependent on lipid receptors

More information:
Nico Fricke et al, The high -resolution imaging field to explore the chemical modulators of the materials of Plasma Membrane Rafts, ACS Central Science (2022). DOI: 10.1021 / accentsci.1c01058

Presented by Vanderbilt University

Directions: Biochemical technology for finding small molecules discovered by researchers (2022, March 28) Retrieved 28 March 2022 from -technique-small-molecules.html

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