April 13, 2022 – Researchers at Harvard University and the Massachusetts Institute of Technology have created a type of bacteria that can protect people from the harmful effects of antibiotics, according to new research in published in a journal. Nature Biomedical Engineering.
While antibiotics remain an important tool in fighting bacterial infections, they can help clear stomach infections, which can lead to diarrhea, diarrhea, or even serious illnesses. such as Clostridioides malignancies. The widespread use of antibiotics has also helped the spread of anti -bacterial microbes around the world. Some doctors have prescribed probiotics to help, although antibiotics can also interfere with probiotics.
“Throughout your life, these organs come together in a very different community to perform important functions in your body,” says Andrés Cubillos-Ruiz, PhD, lead author and research scientist at MIT’s Synthetic Biology Center and Harvard’s Wyss Institute for Biologically Inspired Engineering, said in a statement.
“The problem comes when processes such as drugs or other foods interfere with the creation of the microbiota and create an altered state, called dysbiosis, ”he said. “Some microbial groups disappear, and the metabolic activity of others increases. This imbalance can lead to health problems.”
With a “biotherapeutic survival” – or an engineered bacterial infection – Cubillos -Ruiz and colleagues thought they would have a different outcome. They have changed the nature of Lactococcus lactis, which is safe for humans to eat and is often used in making cheese, provides an enzyme that can break down beta-lactam antibiotics. Most of the different drugs prescribed in the U.S., including penicillin, ampicillin, and amoxicillin, fall under that category.
With gene modification, the researchers altered the way the strain acts on the enzyme to prevent mutations in that ability to other bacterial infections. In other words, the drug reduces the side effects of antibiotics but they can still work against infections.
In a study involving rats, researchers found that engineered bacteria reduced the damage caused by ampicillin, and stomach microbes were restored after 3 days. Stress also slightly reduces antimicrobial resistance genes in the gut microbiome and prevents the loss of fighting microbes. C.sey. In contrast, mice treated with antibiotics had greater damage to stomach microbes and higher levels of C.sey in the stomach.
The research team is working on a type of medication that can be tested in people who are at high risk of getting infections from gut dysbiosis due to antibiotic medications. Finally, they hope to find a cure for the need to take antibiotics for bacterial infections.
“We are currently looking at making these life-saving drugs available to patients and are finalizing the design of a comprehensive, short, and simple clinical trial,” Cubillos-Ruiz said.